Tag: psychedelics
All the articles with the tag "psychedelics".
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Ch. I — Historical arc and sociocultural reframing
Traces the field from Hofmann's 1943 LSD synthesis through Schedule I, the 1990s–2000s renaissance triggers, 2010s mainstreaming, and the 2024 Lykos correction.
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Ch. XII — Methodology, adverse events, and ethics
Cochrane RoB 2.0 applied to flagship trials with worked Muthukumaraswamy 2021 expectancy correction; functional unblinding; suicidality and HPPD; the Lykos MP-4 misconduct forensics.
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Ch. IX — Cognitive enhancement and microdosing
The placebo-controlled microdosing literature; the expectancy-dominated honest verdict; real neurophysiology without behavioural translation; chronic 5-HT2B safety.
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Ch. IV — Systems neuroscience and mechanism
DMN disintegration, entropy, REBUS; the dendritic-spine plasticity literature; the intracellular 5-HT2A thesis; durable connectivity changes.